Final answer:
The statement is true; chromosomes occupy specific regions in the nucleus that can vary by cell type and are important for gene regulation.
Step-by-step explanation:
The statement that chromosomes have defined places in the nucleus that are cell-type dependent is True. In eukaryotic cells, chromosomes have a non-random organization within the nucleus, where specific chromosomes occupy particular territories. This spatial arrangement can differ based on cell type and is thought to be involved in regulating gene expression. Heterochromatin is usually found at the nuclear periphery while euchromatin, which contains active genes, is more centrally located. Additionally, during interphase, the stage of the cell cycle where the cell is not actively dividing, chromosomes are less condensed and exist as a tangle of chromatin, which can be differentiated into euchromatin and heterochromatin by staining. The tightly packed heterochromatin is mostly transcriptionally inactive, while euchromatin is involved in active gene transcription.