Final answer:
Most enhancers do not interact with promoters that reside in adjacent TADs (topology-associated domains). Enhancers can interact with promoter regions containing transcription factors to affect transcription, but they can also interact with distal control elements and mediator proteins for differential gene expression.
Step-by-step explanation:
False. Most enhancers do not interact with promoters that reside in adjacent TADs (topology-associated domains).
Enhancer regions are binding sequences for transcription factors and can be found upstream, downstream, within a gene itself, or on other chromosomes. These enhancers can interact with the promoter regions, which contain transcription factors, to either increase or prevent transcription.
However, enhancers can also interact with distal control elements and mediator proteins. Each gene can have different enhancers and distal control elements, allowing for differential gene expression.