Final answer:
Aberration of the R-point regulating machinery can result in human cancer. Mutations or aberrations in proteins such as Rb and p53 can disrupt normal control mechanisms and lead to uncontrolled cell division.
Step-by-step explanation:
Aberration of the R-point regulating machinery can result in human cancer. The R-point, also known as the restriction point, is a critical checkpoint in the cell cycle where cells decide whether to proceed with division or exit the cell cycle and enter a resting state called the G0 phase. It is regulated by various proteins, including the Rb protein and p53 protein. Mutations or aberrations in these proteins can disrupt the normal control mechanisms and lead to uncontrolled cell division, which can contribute to the development of cancer.