Final answer:
Hyperphosphorylation of pRb leads to transcription activation, not repression.
Step-by-step explanation:
False. Hyperphosphorylation of pRb actually leads to transcription activation, not repression.
Rb, when dephosphorylated, binds to transcription factors, blocking the production of proteins necessary for the G₁/S transition.
As the cell increases in size, Rb is phosphorylated, releasing the transcription factors and allowing gene expression to occur.
When Rb is hyperphosphorylated, it becomes inactive and transcription is activated.