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in what circumstance would a direct antiglobulin test be negative in the presence of a hemolytic process?

User Vilson
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Final answer:

In the presence of a hemolytic process due to G6PD deficiency, the direct antiglobulin test is usually negative.

Step-by-step explanation:

A direct antiglobulin test (also known as a Coombs' test) is used to detect antibodies or complement proteins bound to the surface of red blood cells. In a hemolytic process, such as autoimmune hemolytic anemia or transfusion reactions, the direct antiglobulin test is typically positive. However, in the presence of a hemolytic process due to glucose-6-phosphate dehydrogenase (G6PD) deficiency, the direct antiglobulin test is usually negative. This is because the hemolysis in G6PD deficiency is not immune-mediated.

User Joebarbere
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