Final answer:
Yes, RTKs do activate the PI3-kinase-AKT signaling pathway; this process is crucial for regulating various cellular processes including growth and survival.
Step-by-step explanation:
The statement RTKs activate the PI3-kinase-AKT signaling is true. Receptor Tyrosine Kinases (RTKs) are critical components of cell signaling pathways that influence various cellular processes, including cell division, growth, and survival. After activation by ligands, RTKs undergo autophosphorylation and provide docking sites for downstream signaling molecules like PI3-kinase. The activation of PI3-kinase leads to the production of a second messenger which recruits and activates AKT (also known as Protein Kinase B). AKT then phosphorylates various target proteins, thereby regulating processes such as glucose metabolism, apoptosis, and transcription, as well as contributing to cell growth and survival signaling.