Final answer:
Eukaryotic DNA is separated from the cytoplasm by the nucleus. The nucleus contains DNA wrapped around histones forming nucleosomes, which condense into chromosomes during cell division to ensure each daughter cell gets a complete set of genetic material.
Step-by-step explanation:
Eukaryotic DNA is segregated from the cytoplasm by the nuclear space (Nucleus). In eukaryotic cells, the nucleus serves as the repository for genetic material, separating the DNA from the cellular machinery in the cytoplasm. DNA in the nucleus exists primarily as chromatin, a complex of DNA wrapped around histone proteins, forming a structure known as nucleosomes. When cells prepare to divide during mitosis, this chromatin condenses into chromosomes, ensuring that each daughter cell receives an accurate and complete set of genetic instructions. The nucleus goes through phases of breakdown and reformation around cell division but spends most time in interphase, where it is critically involved in the regulation of genes and the production of different types of RNA.