Final answer:
Enhancers come into contact with σ54 on RNA polymerase through DNA bending proteins that bend the DNA and bring the enhancer and promoter regions together.
Step-by-step explanation:
Enhancers come into contact with σ54 on RNA polymerase through the help of DNA bending proteins. Enhancers are binding sequences for transcription factors, and when a DNA-bending protein binds to the enhancer sequence, it changes the shape of the DNA.
This shape change allows the activators bound to the enhancer to interact with the transcription factors bound to the promoter region and the RNA polymerase, including σ54.
The DNA bending proteins help to bend the DNA and bring the enhancer and promoter regions together, allowing for the interaction between different proteins. This interaction facilitates the initiation of transcription by RNA polymerase.