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Describe Inositol Phosopholipid Signaling (ie. conversion of PI to IP3 and DAG)

User Gimali
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Final answer:

Inositol phospholipid signaling involves the conversion of phosphatidylinositol (PI) to inositol triphosphate (IP3) and diacylglycerol (DAG) through phospholipase C. IP3 releases calcium ions (Ca2+) while DAG activates protein kinase C (PKC).

Step-by-step explanation:

Inositol phospholipid signaling involves the conversion of phosphatidylinositol (PI) to inositol triphosphate (IP3) and diacylglycerol (DAG) through the action of the enzyme phospholipase C. Phospholipase C cleaves phosphatidylinositol bisphosphate (PIP2) into IP3 and DAG. IP3 diffuses into the cytoplasm and binds to calcium channels in the endoplasmic reticulum, leading to the release of calcium ions (Ca2+). DAG remains in the plasma membrane and activates protein kinase C (PKC), which phosphorylates target proteins.

User Sayguh
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