Final answer:
Shifts in an enzyme after binding cause an induced fit between enzyme and substrate, due to a conformational change in the enzyme's structure.
Step-by-step explanation:
The subject of this question is Biology, as the question is about shifts in an enzyme after binding with a substrate.
The shifts in the enzyme after binding cause an induced fit between the enzyme and substrate. This induced fit is due to a conformational change in the enzyme's structure upon binding with the substrate.
For example, the induced-fit model describes how the enzyme and substrate undergo dynamic conformational changes upon binding, allowing the enzyme to contort the substrate into its transition state, thereby increasing the rate of the reaction.