Final answer:
The Rb gene undergoes LOH, which is a genetic event resulting in the loss of one allele of the gene. LOH in the Rb gene can contribute to the development of certain types of cancer, such as retinoblastoma.
Step-by-step explanation:
The Rb gene undergoes LOH, which stands for Loss of Heterozygosity. LOH is a genetic event that occurs when one allele of a gene is lost or mutated, resulting in the loss of genetic diversity in a specific region of DNA.
In the case of the Rb gene, LOH can occur due to various factors such as gene deletion, mutation, or recombination. This loss of heterozygosity can lead to the development of certain types of cancer.
For example, in retinoblastoma, a type of eye cancer, LOH of the Rb gene is commonly observed. In patients with retinoblastoma, both copies of the Rb gene are often lost or mutated, leading to the uncontrolled growth of retinal cells.