Final answer:
The mouse immunoglobulin light chain gene cluster contains 40 variable (V) segments. The variable region of the light chain (VL) is composed of amino acids from position 1 to 108, whereas the constant region (CL) is from 109 to 214. Light chains come in two types, kappa (κ) and lambda (λ), each with hypervariable regions that form the antigen binding site.
Step-by-step explanation:
The mouse immunoglobulin light chain gene cluster consists of 40 variable (V) segments and five joining (J) segments in its germ-line B cells. During the process of V(D)J recombination, an enzyme called DNA recombinase excises most of these segments, leaving only one V segment to join one J segment. Following mRNA processing, a single V and J segment are expressed in the final light chain. The V region of the light chain, known as VL, is composed of amino acids from position 1 to 108 from the N-terminus, whereas the constant region, CL, is from positions 109 to 214.
The light chains themselves can be further categorized into two types: kappa (κ) and lambda (λ). The hypervariable regions present in these light chains, which form the antigen binding site, are regions of extreme amino acid variability and are crucial for the specific binding to antigens.The light chains of the Mouse IG light chain cluster have two V regions. These V₁ regions are located at positions 24-34, 50-56, and 89-97 in the amino acid sequence. These regions are known as hypervariable regions or complementarity determining regions (CDRs) and play a crucial role in antigen binding.