Final answer:
The relationship between KM and enzymatic affinity for the substrate is that a high KM value indicates weak binding, while a low KM value indicates strong binding.
Step-by-step explanation:
The relationship between KM and enzymatic affinity for the substrate is that a high KM value indicates weak binding between the enzyme and the substrate, while a low KM value indicates strong binding.
KM, also known as the Michaelis constant, is a measure of the substrate concentration at which the reaction rate has reached half of its maximum value (Vmax). It is related to the attraction between the enzyme and the substrate.
A smaller KM means the enzyme reacts at smaller substrate concentrations, indicating a stronger attraction between the enzyme and the substrate.