214k views
5 votes
What regions do site specific recombination join in the rearrangement of immunoglobulin light chain genes?

User Paul Ryan
by
8.6k points

1 Answer

5 votes

Final answer:

Site specific recombination in B cells involves the joining of variable (V) and joining (J) segments of immunoglobulin light chain genes to create diverse antibodies.

Step-by-step explanation:

The regions that site specific recombination joins in the rearrangement of immunoglobulin light chain genes are the variable (V) and joining (J) segments. In the development of B cells, DNA recombinase specifically excises and joins these V and J segments to generate a diverse array of antibodies.

Each B cell hence will typically display a unique immunoglobulin with a unique variable region capable of binding different antigens, a mechanism critical for the adaptive immune response.

User Germi
by
7.4k points