Final answer:
The PI3K/Akt pathway is involved in many types of human cancers, not just one; its over-activation contributes to tumorigenesis. Gene mutations in pathways and proteins like EGFR and HER2 lead to various cancers, and drugs like Lapatinib target these pathways for treatment.
Step-by-step explanation:
The statement "PI3K/Akt over-activation is associated with only one type of human cancer" is false.
The PI3K/Akt pathway is a critical signaling pathway that, when over-activated, is implicated in the development of many types of cancer.
This pathway is involved in cell proliferation, survival, and metabolism, among other cellular functions.
Gene mutations and overexpression of proteins in this pathway, such as receptor tyrosine kinases like EGFR and HER2, are observed in various cancers including breast, lung, and pancreatic cancers.
Inhibitors targeting this pathway, like Lapatinib which inhibits the HER2 receptor, are used in cancer treatment to prevent further cell growth and division.