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Where do extrinsic and intrinsic apoptotic pathways converge?

User Jsgoupil
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Final answer:

The extrinsic and intrinsic apoptotic pathways converge at the point of cytochrome C release into the cytoplasm.

Step-by-step explanation:

The extrinsic and intrinsic apoptotic pathways converge at the point of cytochrome C release into the cytoplasm. In the extrinsic pathway, damage to the surrounding tissues triggers the release of factor III (thromboplastin). This factor activates the extrinsic pathway, leading to the activation of caspases, which ultimately induce apoptosis. In the intrinsic pathway, internal damage to the vessel wall triggers the release of cytochrome C from the mitochondria into the cytoplasm. Cytochrome C then binds to adaptor proteins, forming a complex with procaspase and activating caspases, which also induce apoptosis.

User Mkasberg
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