Final answer:
Type I nuclear receptors (NRs) are activated by specific hormones and function as hormone-activated transcription factors.
Step-by-step explanation:
Type I nuclear receptors (NRs) are activated by specific hormones and function as hormone-activated transcription factors. When a hormone binds to the receptor, it dissociates from a heat shock protein and translocates to the nucleus. In the nucleus, the hormone-receptor complex binds to a DNA sequence called a hormone response element (HRE), which triggers gene transcription and translation. These receptors include those for thyroid hormones, glucocorticoids, estrogens, androgens, calcitriol, retinoids, and others.