Final answer:
The most frequently over-copied receptor in human glioblastomas is the Epidermal Growth Factor Receptor (EGFR), which leads to uncontrolled cellular proliferation when mutated and overexpressed.
Step-by-step explanation:
The most frequently over-copied receptor in human glioblastomas is the Epidermal Growth Factor Receptor (EGFR), also known as the first enzyme-linked tyrosine kinase discovered. EGFR is a cell-surface receptor that, when mutated, is associated with various forms of cancer, including glioblastoma. Glioblastomas often exhibit gene amplification and overexpression of EGFR, which leads to excessive signaling for cell growth and replication, contributing to the malignancy and proliferation of cancer cells.
In the context of glioblastoma, targeted therapies have been developed to inhibit the EGFR signaling pathway, aiming to control tumor growth. EGFR is part of a wider family of receptors, which includes HER2, known to be overexpressed in a significant subset of breast cancers. For HER2 positive breast cancer, drugs like Herceptin (trastuzumab), which is a monoclonal antibody, have been effective in increasing the overall survival rate of patients by targeting the HER2 receptor.