Final answer:
In the oxidation of NADH, the hydride ion produced is transferred to NAD+, reducing it to NADH, which is an important step in the electron transport chain leading to the formation of water.
Step-by-step explanation:
During the oxidation of NADH, a hydride ion (H-) is produced. This hydride ion is a powerful nucleophile and is immediately transferred to NAD+, reducing it to NADH in a one-step redox reaction. The hydride transfer is considered a conjugate nucleophilic addition.
In metabolic pathways, this is an essential step as it facilitates the transfer of electrons through the electron transport chain. Ultimately, the electrons released by NADH are captured by oxygen at the end of the electron transport chain, resulting in the formation of water.