Final answer:
Vesicle transport (endocytosis and exocytosis) is used for the movement of large molecules and multimolecular particles between the ECF and ICF.
Step-by-step explanation:
Large molecules and multimolecular particles are transported between the extracellular fluid (ECF) and intracellular fluid (ICF) using vesicle transport.
This form of active transport involves the movement of macromolecules across the plasma membrane through the use of vesicles.
There are two types of vesicle transport: endocytosis (moving molecules into the cell) and exocytosis (moving molecules out of the cell). Both processes require energy.