Question

Site ____ on the tRNA accommodates looser base-pairing rules

Answer 1

The site on tRNA that accommodates looser base-pairing rules is the **wobble position**. The wobble hypothesis proposes that the base pairing at the third position of a codon (in mRNA) and the anticodon (in tRNA) is less stringent, allowing for non-standard base pairing. This flexibility in base pairing is particularly relevant in the third position of the codon and the first position of the anticodon, and it is known as the wobble base pairing. This adaptability helps in expanding the coding capacity of the genetic code without requiring a separate tRNA for each possible codon.

Answer 2

The site on the tRNA that accommodates looser base-pairing rules is the wobble position, allowing for non-standard base pairing during translation.

Step-by-step explanation:

The site on the tRNA that accommodates looser base-pairing rules is the wobble position. This position allows for non-standard base pairing between the tRNA anticodon and the mRNA codon during translation.

For example, the wobble position allows a tRNA with the anticodon 5'-UAC-3' to recognize both the codons 5'-GUA-3' and 5'-GUG-3', because the third position in the codon can form non-standard base pairs.

This flexibility in base pairing at the wobble position helps increase the efficiency and speed of translation by allowing a single tRNA to recognize multiple codons with similar sequences.