Final answer:
Glyceraldehyde-3-phosphate and 1,3-bisphosphoglycerate are the intermediates that accumulate most when glyceraldehyde-3-phosphate dehydrogenase is inhibited in red blood cells.
Step-by-step explanation:
Inhibition of glyceraldehyde-3-phosphate dehydrogenase in red blood cells leads to the accumulation of glyceraldehyde-3-phosphate and 1,3-bisphosphoglycerate, which are the intermediates in glycolysis that precede the enzyme's activity.