194k views
2 votes
What does MHC restriction mean and what cells does it refer to?

User Web Worm
by
7.5k points

1 Answer

1 vote

Final answer:

MHC restriction refers to the requirement for T cells to recognize antigens presented on MHC molecules. MHC I presents antigens from inside the cell, while MHC II presents antigens from outside the cell. This recognition is crucial for the activation of the adaptive immune system.

Step-by-step explanation:

MHC restriction refers to the requirement for T cells to recognize antigens presented on major histocompatibility complex (MHC) molecules in order to initiate an immune response. There are two classes of MHC molecules, MHC I and MHC II. MHC I molecules are found on all nucleated cells and present antigens from inside the cell, while MHC II molecules are found on macrophages, dendritic cells, and B cells, and present antigens from outside the cell. The recognition of antigens by T cells through MHC restriction is crucial for the activation of the adaptive immune system.

User Kalita Alexey
by
8.7k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.