Final answer:
A genetic defect in IRAK4 would likely lead to increased rates of bacterial infection due to a compromised MyD88-dependent innate immune response, which is crucial for fighting off bacteria.
Step-by-step explanation:
A genetic defect in IRAK4, which is a protein required for the MyD88 pathway, would likely result in an increased rate of bacterial infection. The MyD88-dependent pathway is involved in the innate immune response, particularly in the signaling mechanisms following the recognition of pathogens by Toll-like receptors (TLRs). When IRAK4 is dysfunctional due to a genetic mutation, this pathway is compromised, leading to an impaired immune response.
Patients with an IRAK4 deficiency have been shown to suffer from recurrent, often life-threatening, bacterial infections. The inability of their immune system to adequately signal via the MyD88 pathway hinders the production of essential pro-inflammatory cytokines and downstream immune responses that are critical for fighting off bacteria.