Question

Which of the following would you predict to result from a mutation in TLR-4 that prevents binding to LPS?

A. Increased susceptibility to infection with gram-positive bacteria
B. Decreased susceptibility to septic shock
C. Failure to develop from an embryo
D. Tighter binding between bacteria and macrophages
E. Increased phagocytosis

Answer 1

A mutation in TLR-4 that prevents binding to LPS would result in decreased susceptibility to septic shock.

Step-by-step explanation:

A mutation in TLR-4 that prevents binding to LPS would result in decreased susceptibility to septic shock. TLR-4 is a receptor on immune cells that recognizes LPS, which is released by gram-negative bacteria. Binding of LPS to TLR-4 triggers the immune response that leads to septic shock. If TLR-4 cannot bind to LPS due to the mutation, the immune response and the associated inflammatory reactions would be dampened, resulting in reduced susceptibility to septic shock.