Question

Match the following toll-like receptors with their ligands.

TLR Ligands
TLR3 Flagellin
TLR4 Zymosan
TLR5 dsRNA
TLR6 CpG unmethylated dinucleotides
TLR9 LPS

A. TLR3/LPS; TLR4/CpG unmethylated dinucleotides; TLR5/dsRNA; TLR6/Zymosan; TLR9/Flagellin
B. TLR3/dsRNA; TLR4/LPS; TLR5/Flagellin; TLR6/Zymosan; TLR9/CpG unmethylated dinucleotides
C. TLR3/dsRNA; TLR4/LPS; TLR5/CpG unmethylated dinucleotides; TLR6/Flagellin; TLR9/Zymosan
D. TLR3/CpG unmethylated dinucleotides; TLR4/Zymosan; TLR5/Flagellin; TLR6/LPS; TLR9/dsRNA
E. TLR3/Zymosan; TLR4/LPS; TLR5/Flagellin; TLR6/dsRNA; TLR9/CpG unmethylated dinucleotides

Answer 1

The correct matching of TLRs to their ligands is TLR3 with dsRNA, TLR4 with LPS, TLR5 with Flagellin, TLR6 with Zymosan, and TLR9 with CpG unmethylated dinucleotides.

Step-by-step explanation:

Toll-like receptors (TLRs) are a vital component of the innate immune system, recognizing pathogen-associated molecular patterns (PAMPs) and initiating an immune response. Each TLR is known for binding to specific ligands, which are molecules often found on the surface of pathogens.

The correct match of TLRs to their ligands is:

• TLR3 binds dsRNA which is typically found in viruses.
• TLR4 recognizes Lipopolysaccharides (LPS), which are common on the surface of gram-negative bacteria.
• TLR5 binds Flagellin, a component of bacterial flagella.
• TLR6 forms heterodimers with TLR2 and can bind to Zymosan, a component of fungal cell walls, among other ligands.
• TLR9 binds to CpG unmethylated dinucleotides, a motif frequently found in bacterial and viral DNA.

Therefore, the correct match is option B: TLR3/dsRNA; TLR4/LPS; TLR5/Flagellin; TLR6/Zymosan; TLR9/CpG unmethylated dinucleotides.