Question

Which of the following describes two recombination signal sequences required for a permitted somatic recombination event?

a. VH 7-12- 9-23-7 JH
b. V(lambda) 7-23- 9-23-7 J(lambda)
c. DH 7-12- 9-23-7 JH
d. VK 7-12- 7-23-9 JK
e. VH 9-23- 7-12-9 DH

Answer 1

The recombination signal sequences required for a permitted somatic recombination event in germ-line B cells are the V (Variable) and J (Joining) segments.

Step-by-step explanation:

The recombination signal sequences required for a permitted somatic recombination event in germ-line B cells are actually the V (Variable) and J (Joining) segments.

For the light chain gene, there are 40 variable (V) segments and five joining (J) segments. The DNA recombinase enzyme randomly excises most of these segments and splices one V segment to one J segment during the recombination process.

Therefore, the correct option out of the given choices is b. V(lambda) 7-23- 9-23-7 J(lambda), which represents the recombination signal sequences required for somatic recombination.