Final answer:
Cryo-ultramicrotomy is the electron microscope technique that involves striking a frozen specimen with a knife-edge to crack the ice and interact with tissue. It is used to prepare specimens for the Transmission Electron Microscope (TEM).
Step-by-step explanation:
The electron microscope technique that involves striking a frozen specimen with a knife-edge to crack the ice and interact with tissue is called cryo-ultramicrotomy. This technique is used to prepare specimens for the Transmission Electron Microscope (TEM). In cryo-ultramicrotomy, the specimen is frozen and then sectioned using an ultramicrotome to obtain thin slices for electron microscopy.