Final answer:
True. To exit the ER, proteins must be folded correctly.
Step-by-step explanation:
True. To exit the ER, proteins must be folded correctly. Many proteins fold spontaneously, but some proteins require helper molecules, called chaperones, to prevent them from aggregating during the complicated process of folding. Even if a protein is properly specified by its corresponding mRNA, it could take on a completely dysfunctional shape if abnormal temperature or pH conditions prevent it from folding correctly.