Question

A long poly-A-tail is necessary to initiate translation. Which protein binds directly to eIF4E to inhibit

translation initiation?
A) maskin
B) PABP
C) CPEB
D) PARN
E) poly-A polymerase

Answer 1

The protein that inhibits translation initiation by binding to eIF4E is maskin, a regulatory protein that controls mRNA translation in eukaryotic cells.

Step-by-step explanation:

The protein that binds directly to eIF4E to inhibit translation initiation is maskin. This occurs as part of the regulatory mechanisms controlling mRNA translation in eukaryotic cells. The eukaryotic initiation factor 4E (eIF4E) is a component of the eIF4F complex, which is crucial for the recruitment of mRNA to the ribosome. eIF4F recognizes and binds to the 5' cap structure of the mRNA. Proteins that inhibit this interaction can prevent the formation of the initiation complex and thus downregulate translation.