Final answer:
Crossing over occurs during prophase I of meiosis, particularly during synapsis when homologous chromosomes pair tightly and form a synaptonemal complex, enabling the exchange of genetic material.
Step-by-step explanation:
Crossing over occurs during prophase I of meiosis, more specifically during the sub-stage known as synapsis. This is the stage when homologous chromosomes pair up very tightly and form a structure known as a synaptonemal complex. The close pairing is called synapsis, which allows for the alignment of genes on the chromatids of homologous chromosomes and supports the exchange of chromosomal segments between non-sister homologous chromatids, a process called crossing over. After crossing over, the homologous chromosomes remain connected at points called chiasmata, and because four sister chromatids are visible, they form a structure known as a tetrad.
So, crossing over occurs: B) at the four-strand stage of meiosis, after synapsis of homologous chromosomes, and before the end of prophase I.