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Where do polar side chains tend to fall in a folded protein?

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Final answer:

Polar side chains tend to fall on the outer surface of a folded protein, interacting with water molecules. Hydrophobic side chains are found in the interior of the protein, away from water.

Step-by-step explanation:

In folded proteins, polar side chains tend to fall on the outer surface of the molecule. These hydrophilic side chains interact with water molecules, helping to dissolve the protein. The hydrophobic side chains, on the other hand, are found in the interior of the protein, away from water.

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