Final answer:
Nonpolar side chains of amino acids in proteins tend to fall in the interior of the folded protein.
Step-by-step explanation:
Nonpolar side chains of amino acids in proteins tend to fall in the interior of the folded protein. Hydrophobic R groups interact with each other through van der Waals forces, while hydrophilic R groups face outwards.
The interactions between these side chains determine the final three-dimensional shape of the protein.