Final answer:
High doses of chelating agents like penicillamine or trientine are used to treat Wilson's disease, a genetic disorder that causes copper buildup in the body, leading to liver and neurological damage.
Step-by-step explanation:
High doses of specific chelating agents, particularly penicillamine or trientine, can help in the treatment of Wilson's disease. Wilson's disease is a rare hereditary disorder that leads to excessive accumulation of copper in the body, causing hepatocellular damage and neurological symptoms.
Treatment usually involves reducing dietary copper intake and using medications that bind to copper (chelate), allowing it to be eliminated from the body. In severe cases, hepatocellular transplantation may be required. Wilson's disease is often associated with various conditions such as severe hypo-proteinemia, vitamin K deficiency, and sometimes hepatic disorders like primary sclerosing cholangitis or primary biliary cirrhosis.