Question

TBP: Which of the following statements is FALSE?

-TBP is found in eukaryotes and in Archaea.
-TBP is found in a major group of prokaryotes.
-TPB is able to form a kink in the DNA by the insertion of glycine residues into the TATAA.
-TBP binds to the minor grove of DNA.
-TFIIB binds to the C-terminal stirrup of TBP.

Answer 1

TBP binds to the major groove of DNA to initiate transcription. The statement 'TBP binds to the minor groove of DNA' is FALSE.

Step-by-step explanation:

The statement that is FALSE is: TBP binds to the minor groove of DNA. TBP (TATA-binding protein) actually binds to the major groove of DNA to initiate transcription. It recognizes the TATA box, a specific DNA sequence found in eukaryotes and Archaea. TBP helps in the formation of the pre-initiation complex by recruiting other transcription factors, including TFIIB.