Question

Transactivators play multiple roles in the activation of transcription. Which of the following is NOT a role played by transactivators?

-assist the helicases in the core module of TFIIH in melting the promoter
-recruit basal transcription factors such as TFIID and TFIIB.
- recruit HAT containing co-activator complexes
- recruit SWI/SNF chromatin remodeling complexes

Answer 1

Transactivators do not assist helicases in melting the promoter. They recruit basal transcription factors, co-activator complexes, and chromatin remodeling complexes to facilitate transcription initiation.

Step-by-step explanation:

Transactivators play multiple roles in the activation of transcription. However, assisting helicases in the core module of TFIIH in melting the promoter is NOT a role played by transactivators. Transactivators recruit basal transcription factors such as TFIID and TFIIB, recruit HAT containing co-activator complexes, and recruit SWI/SNF chromatin remodeling complexes. These activities help in the assembly of a preinitiation complex on the DNA template and the recruitment of RNA polymerase II for transcription initiation.

Answer 2

Transactivators are key in recruiting essential transcription factors and complexes, but they do not assist helicases in melting the promoter during transcription initiation.

Step-by-step explanation:

Transactivators play critical roles in the activation of eukaryotic transcription but do not assist helicases in melting the promoter. Transactivators are known to recruit basal transcription factors such as TFIID and TFIIB, recruit HAT containing co-activator complexes, and recruit SWI/SNF chromatin remodeling complexes to regulate transcription. These factors altogether facilitate the assembly of a preinitiation complex which is essential for initiating transcription. However, the direct involvement in DNA unwinding through assisting helicases is not a role of transactivators; rather, it's a function of the core module of TFIIH within the transcription complex.