Final answer:
Hypomethylation or hypermethylation therapies can cause normal tissues to become cancerous and can lead to the development of different types of cancer. The complex regulatory systems involved in cancer mean that different types of cancer may respond differently to these therapies. Additionally, each therapy depends on the specific environment of the organ affected by cancer.
Step-by-step explanation:
Hypomethylation or hypermethylation therapies affect both cancer cells and surrounding tissues, causing normal tissues to become cancerous. Since there are multiple routes that lead to cancer, one would expect complex regulatory systems to be involved. Despite how these therapies alter cancer cells, some tumors can change during therapy which allow them to adapt to the treatment and thrive from it. Each of these therapies depends on an organ-specific environment, resulting in cancers in different environments responding differently.