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RNA pol I promoter: Which of the following complexes contains TBP as a subunit?

-B
-SL1
-TFIIIC
-Brf
-UBF

User PrathapG
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1 Answer

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Final answer:

The complex that contains TBP as a subunit for RNA polymerase I promoter is SL1. TFIID, which also contains TBP, is specific to RNA polymerase II and binds to the promoter region's TATA box to assist in the transcription of mRNA.

Step-by-step explanation:

The student has asked about the components of eukaryotic transcription factors and specifically, which complexes contain the TATA-binding protein (TBP) as a subunit. Among the options provided, the correct answer is SL1, which is associated with RNA Polymerase I and is involved in the transcription of ribosomal RNA genes (rRNA).

TFIID is the transcription factor essential for RNA Polymerase II that recognizes and binds to the TATA box within the promoter region of protein-coding genes. This binding of TFIID helps in recruiting other transcription factors like TFIIB, TFIIE, TFIIF, and TFIIH which contribute in forming the transcription initiation complex necessary for the transcription of mRNA.

It's noteworthy that TBP is a subunit of TFIID, which is specific to RNA polymerase II, and while RNA polymerase I also utilizes a TATA binding protein, it does so within the context of the SL1 complex, not TFIID.

User Wim Coenen
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