Final answer:
The false statement is that TBP, a subunit of TFIID, has no interaction with SAGA. This is incorrect because the TATA-binding protein (TBP) within TFIID does interact with SAGA. Both TFIID and SAGA play crucial roles in transcription initiation and regulation in eukaryotes.
Step-by-step explanation:
When discussing TFIID and SAGA, it's important to know that both are involved in the regulation of gene expression at the level of transcription. The false statement among the options provided is "TBP is a subunit of TFIID and has no interaction with SAGA". This is incorrect because the TATA-binding protein (TBP), which is a subunit of TFIID, does indeed interact with SAGA, contradicting the claim in the statement that there is no interaction.
To elaborate on the aspects presented in the question, TFIID is a factor that recognizes and binds to the TATA box within the core promoter region of genes and is essential for the recruitment of other transcription factors and the formation of the preinitiation complex. TFIID includes TBP and multiple TAFs (TBP-associated factors). One of the TAFs, TAF1, does have histone acetyltransferase (HAT) activity.
SAGA (Spt-Ada-Gcn5 acetyltransferase) is a multi-subunit coactivator that also contains HAT activity, crucial for chromatin modification and transcription activation. Within SAGA, GCN5 is the catalytic subunit responsible for the HAT activity. Additionally, both SAGA and TFIID contain TAFs, contributing to the complexity of transcriptional regulation.
In summary, both TFIID and SAGA are key to the initiation and regulation of transcription, with TBP of TFIID interacting with SAGA, in contrast to one of the statements provided by the student.