Final answer:
The correct statement about natural selection is that it acts directly on phenotypes and only indirectly on genotypes, influencing the frequencies of alleles within a population.
Step-by-step explanation:
The statement that is true regarding natural selection is C: Natural selection acts directly on phenotypes, and only indirectly on genotypes. Natural selection acts on the physical phenotypes that are expressed by organisms as a result of their genetic makeup. These phenotypes are what gives individuals varying levels of success in their environment, which leads to differences in survival and reproduction. It is through this process that genotypes are indirectly affected, as the alleles that contribute to successful phenotypes become more common in the population over time.