Final answer:
The movement of Ca2+ into the matrix from the intermembrane space might require co-transport of protons from the mitochondrial intermembrane space to the matrix.
Step-by-step explanation:
The movement of Ca2+ into the matrix from the intermembrane space might require co-transport of protons from the mitochondrial intermembrane space to the matrix, as it could not be driven solely by the membrane potential across the inner membrane. Ca2+ is an example of an ion that moves against its concentration gradient.