Final answer:
Unequal crossover during meiosis in repetitive DNA regions commonly results in chromosomal aberrations, such as duplications and deletions, which can lead to genetic disorders.
Step-by-step explanation:
A common consequence of unequal crossover between homologs in repetitive DNA regions of the chromosome is the creation of genetic imbalances, such as duplications and deletions. During meiosis, crossover events between homologous chromatids result in the exchange of genetic material, leading to genetic variation. However, when crossover is unequal, it can lead to chromosomal aberrations. For instance, one chromatid may end up with duplicated DNA segments while the other may have deletions. This misalignment typically occurs in regions where DNA sequences are highly repetitive and can increase the likelihood of unequal crossing-over. Such genetic changes can have significant consequences, potentially leading to disorders or diseases depending on the importance of the affected genes.