Final answer:
Heterochromatin contains permanently turned off genes in a mammalian cell, but it is not highly concentrated in the centromeres.
Step-by-step explanation:
In a typical mammalian cell, all of the statements regarding heterochromatin are true except for option A. Heterochromatin contains genes that are not expressed, therefore, option B is true. The genes that are packaged in heterochromatin are generally in a permanently turned off state, making option C true. Different types of heterochromatin do share a high degree of compaction, thus option D is true. However, heterochromatin is not highly concentrated in the centromeres but it is concentrated in the telomeres, making option E false.