Question

Which of the following tRNA sequences would you expect to find in a patient suffering from MERRF syndrome?

A) 5'-GAA-3'
B) 5'-CUU-3'
C) 5'-AAG-3'
D) 3'-GAA-5'
E) 3'-CUU-5'

Answer 1

The tRNA sequence you would expect to find in a patient with MERRF syndrome is 5'-CUU-3' (option B).

Step-by-step explanation:

MERRF syndrome, also known as myoclonic epilepsy with ragged-red fibers, is a rare mitochondrial disorder. It is caused by mutations in the mitochondrial DNA tRNA gene, which leads to impaired protein synthesis within the mitochondria. In the case of MERRF syndrome, the specific tRNA mutation is typically found in the tRNALys gene. As a result, the correct tRNA sequence for a patient suffering from MERRF syndrome would be 5'-CUU-3' (option B).