Question

The goal of gene-therapy techniques is to provide cells with functional copies of mutated genes. One technique involves introducing functional genes on an "artificial chromosome." Somatic cells in which the artificial chromosome has been inserted have 47 chromosomes instead of the normal 46 (i.e., for human cells). To be effective, the artificial chromosome must be passed to daughter cells during mitosis, which requires that the artificial chromosome contain sequences on which kinetochores can assemble. With this in mind, what should designers of artificial chromosomes include to ensure proper kinetochore assembly on the artificial chromosome?

Answer 1

Designers of artificial chromosomes should include the centromere, telomeres, and other necessary DNA sequences for proper kinetochore assembly.

Step-by-step explanation:

To ensure proper kinetochore assembly on the artificial chromosome, designers should include the necessary DNA sequences for kinetochore formation. These DNA sequences include the centromere and other repetitive regions that can bind specific proteins and form the kinetochore complex. The artificial chromosome must also contain telomeres, which are protective structures at the ends of chromosomes. By including these essential sequences, the artificial chromosome can be properly passed to daughter cells during mitosis, allowing for effective gene therapy.