Question

What would happen if you change the hydrophobic amino acids in an ER signal sequence into charged amino acids.

A) The altered signal sequence will not be recognized and the protein will remain in the cytosol.
B) The altered signal sequence will not be recognized and the protein wilI remain in the ER until a chaperone protein can modify the sequence to contain an ER signal
C) The altered signal sequence will cause the protein to be tagged with ubiquinone for degradation
D) The altered signal sequence will immediately cause the cell to undergo apoptosis

Answer 1

If you change the hydrophobic amino acids in an ER signal sequence into charged amino acids, the altered signal sequence will not be recognized and the protein will remain in the cytosol.

Step-by-step explanation:

If you change the hydrophobic amino acids in an ER signal sequence into charged amino acids, the altered signal sequence will not be recognized and the protein will remain in the cytosol (Option A). The hydrophobic amino acids in the signal sequence are necessary for the protein to be recognized and properly transported to the endoplasmic reticulum (ER). When these hydrophobic amino acids are changed into charged amino acids, the signal sequence loses its ability to interact with the cellular factors responsible for transporting the protein to the correct compartment.