Final answer:
Ligases are enzymes that catalyze the formation of phosphodiester linkages in DNA fragments, playing a crucial role in DNA replication and repair.
Step-by-step explanation:
Ligases are enzymes that catalyze the formation of a phosphodiester linkage between the 3' OH and 5' phosphate ends of DNA fragments. They play a critical role in the process of DNA replication and repair.
For example, during DNA replication, the leading strand is synthesized continuously in the 5'-3' direction. After the Okazaki fragments are synthesized on the lagging strand, ligase is responsible for joining them together into a continuous DNA strand.
Therefore, the statement 'Ligase catalyzes all stages of integration' is false.