Question

In some cases of B-cell lymphoma, translocation of bcl-2 into the Ig locus results in overexpression of this gene. Knowing what you do about lymphoma and cancer, what do you predict is the function of bcl-2?

A. It lowers the threshold for negative selection.
B. It inhibits apoptosis.
C. It regulates expression of IL-2.
D. It is responsible for TH2 differentiation.
E. None of the above

Answer 1

Bcl-2 inhibits apoptosis in cases of B-cell lymphoma.

Step-by-step explanation:

The function of bcl-2 in cases of B-cell lymphoma, where translocation of bcl-2 into the Ig locus results in overexpression of this gene, is that it inhibits apoptosis.

Answer 2

In cases of B-cell lymphoma involving translocation of bcl-2 into the Ig locus, the overexpression of bcl-2 suggests its role in inhibiting apoptosis. Option B is the answer.

Step-by-step explanation:

Bcl-2 is a key anti-apoptotic protein that regulates the intrinsic mitochondrial pathway of apoptosis. In normal conditions, apoptosis is a controlled process that eliminates damaged or unnecessary cells. However, overexpression of bcl-2 can disrupt this balance, preventing programmed cell death and contributing to the survival and proliferation of cancerous B cells.

The correct prediction aligns with option B, as bcl-2's anti-apoptotic function is a well-established mechanism in the context of B-cell lymphoma and other cancers.

Option B is the answer.