Question

Which of the following does NOT occur shortly following oligomerization of the BCR upon antigen binding?

A. Movement of the BCR complex into areas of the membrane called "lipid rafts"
B. Positioning of Igα and Igβ to allow for phosphorylation of their ITAM motifs
C. Positioning of CD3 to allow for phosphorylation if its ITAM motifs
D. Formation of clathrin-coated pits around BCR complex
E. All of the above occur.

Answer 1

Formation of clathrin-coated pits around the BCR complex does NOT occur following oligomerization of the BCR upon antigen binding.

Step-by-step explanation:

Upon oligomerization of the BCR upon antigen binding, the formation of clathrin-coated pits around the BCR complex does NOT occur.

When the BCR is oligomerized upon antigen binding, several other events occur:

1. Movement of the BCR complex into areas of the membrane called "lipid rafts"
2. Positioning of Igα and Igβ to allow for phosphorylation of their ITAM motifs
3. Positioning of CD3 to allow for phosphorylation of its ITAM motifs