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Which cells that are found within GC light zones are generally NOT found in the GC dark zones?

A. Differentiating B cells
B. TFH cells
C. FDCs
D. Naïve IgD+ B cells that are not participating in the response to the antigen
E. None of the above

User Christijk
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1 Answer

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Final answer:

The cells found within the germinal center light zones but not in the dark zones are Follicular Dendritic Cells (FDCs). They help in the affinity maturation of B cells. The correct answer is C. FDCs.

Step-by-step explanation:

The cells typically found within the germinal center (GC) light zones, but not in the GC dark zones, are Follicular Dendritic Cells (FDCs). The light zones of germinal centers are primarily concerned with the selection of B cells that have undergone somatic hypermutation. FDCs present antigens to these B cells, thus promoting the affinity maturation of antibodies. The answer to the question is C. FDCs. Germinal centers are sites within secondary lymphoid organs where mature B cells proliferate, differentiate, and mutate their antibody genes through somatic hypermutation to increase the affinity of antibodies for their antigens.

Contrarily, Naïve IgD+ B cells that are not participating in the response to antigen, as well as differentiating and activated B cells, can be found in both the light and dark zones. TFH cells, a subset of T cells, are also present in both zones as they assist in the selection and survival of B cells that produce high-affinity antibodies.

User Simon Streicher
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